The RNA-binding ubiquitin ligase MKRN1 functions in ribosome-associated quality control of poly(A) translation

Abstract Background Cells have evolved quality control mechanisms to ensure protein homeostasis by detecting and degrading aberrant mRNAs and proteins.A common source of aberrant mRNAs is premature polyadenylation, which can result in non-functional protein products.Translating ribosomes that encounter poly(A) sequences are terminally Wooden Blocks

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